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. 2008 Aug;38(8):534-9.
doi: 10.1093/jjco/hyn072. Epub 2008 Aug 9.

Trends in lung cancer incidence by histological type in Osaka, Japan

Yasuhiro Toyoda  1 , Tomio Nakayama, Akiko Ioka, Hideaki Tsukuma
Affiliations

Trends in lung cancer incidence by histological type in Osaka, Japan

Yasuhiro Toyoda et al. Jpn J Clin Oncol. 2008 Aug.

Abstract

Background: In Japan, an increase in age-adjusted incidence rates of lung adenocarcinoma (ADC) and a decrease in lung squamous cell carcinoma (SQCC) have been reported.

Methods: The number of lung cancer incidence, age-adjusted rates, and age-specific rates by birth-cohort according to histological type were examined using the data from Osaka Cancer Registry.

Results: The numbers of lung cancer incidence among men and women have increased, particularly in ADC. The age-adjusted incidence rates of ADC among men and women have continuously increased, while those of SQCC and small cell carcinoma (SMCC) turned to decrease since 1990s. A trough of lung cancer incidence rates was observed among men in 1935-39 birth-cohorts. The declining trend appeared in 1955-59 birth-cohorts. Lung cancer incidence rates among women have increased since 1895-99 birth-cohorts, but those rates leveled off or decreased in 1950s birth-cohorts. Trends of ADC by birth-cohort were almost the same as those of all histological types. The SQCC among men peaked in 1915-19 birth-cohorts, and decreased in the subsequent birth-cohorts. The SMCC among men peaked in 1920s birth-cohorts, and decreased or leveled off in the subsequent birth-cohorts.

Conclusions: Lung cancer incidence rates by birth-cohorts were almost parallel to the smoking prevalence. However, those for ADC among young women in 1950s birth-cohorts were not parallel to the smoking prevalence, which requires careful monitoring to confirm such findings.

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Figures

Figure 1.
Figure 1.
Trends in age-group-specific lung cancer incidence rates with 95% confidence interval by birth-cohort for all histological types.
Figure 2.
Figure 2.
Trends in age-group-specific incidence rates with 95% confidence interval by birth-cohort for adenocarcinoma.
Figure 3.
Figure 3.
Trends in age-group-specific incidence rates with 95% confidence interval by birth-cohort for squamous cell carcinoma.
Figure 4.
Figure 4.
Trends in age-group-specific incidence rates with 95% confidence interval by birth-cohort for small cell carcinoma.
See this image and copyright information in PMC

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