Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Sep:29 Suppl 2:S233-4.
doi: 10.1007/s10072-008-0947-9.

Cyclophosphamide-based combination therapies for autoimmunity

Paola Perini  1 , Massimiliano Calabrese, Luciano Rinaldi, Paolo Gallo
Affiliations
Review

Cyclophosphamide-based combination therapies for autoimmunity

Paola Perini et al. Neurol Sci. 2008 Sep.

Abstract

Immunomodulatory agent (IMA)-unresponsive multiple sclerosis (MS) can quickly evolve to a dramatic and irreversible disability. Treating these patients with appropriate immunosuppressive therapies can be a chance to arrest disease activity and progression. Cyclophosphamide (Cyc)-based intense immunosuppression has been successfully used to treat rapidly deteriorating, IMA-refractory MS patients. Therapeutic protocols combining Cyc and interferon beta (IFNbeta) have also been successfully applied to treat IFNbeta-unresponsive MS. The association of Cyc with other immunomodulatory drugs or monoclonal antibodies is currently being investigated in clinical trials aimed at treating severe forms of autoimmune diseases.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Clin Invest. 1998 Aug 15;102(4):671-8 - PubMed
    1. J Neurol Sci. 2004 Aug 15;223(1):1-11 - PubMed
    1. Mult Scler. 2005 Oct;11(5):573-82 - PubMed
    1. Semin Arthritis Rheum. 1983 May;12(4):359-72 - PubMed
    1. Ann Intern Med. 1995 Jun 15;122(12):940-50 - PubMed

MeSH terms

LinkOut - more resources