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Review
. 2008 Sep:29 Suppl 2:S233-4.
doi: 10.1007/s10072-008-0947-9.

Cyclophosphamide-based combination therapies for autoimmunity

Paola Perini  1 , Massimiliano Calabrese, Luciano Rinaldi, Paolo Gallo
Affiliations
Review

Cyclophosphamide-based combination therapies for autoimmunity

Paola Perini et al. Neurol Sci. 2008 Sep.

Abstract

Immunomodulatory agent (IMA)-unresponsive multiple sclerosis (MS) can quickly evolve to a dramatic and irreversible disability. Treating these patients with appropriate immunosuppressive therapies can be a chance to arrest disease activity and progression. Cyclophosphamide (Cyc)-based intense immunosuppression has been successfully used to treat rapidly deteriorating, IMA-refractory MS patients. Therapeutic protocols combining Cyc and interferon beta (IFNbeta) have also been successfully applied to treat IFNbeta-unresponsive MS. The association of Cyc with other immunomodulatory drugs or monoclonal antibodies is currently being investigated in clinical trials aimed at treating severe forms of autoimmune diseases.

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