Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep;95(9):1180-4.
doi: 10.1002/bjs.6242.

Adipose-derived mesenchymal stem cells in biosutures do not improve healing of experimental colonic anastomoses

I Pascual  1 , G Fernández de Miguel, U A Gómez-Pinedo, F de Miguel, M García Arranz, D García-Olmo
Affiliations

Adipose-derived mesenchymal stem cells in biosutures do not improve healing of experimental colonic anastomoses

I Pascual et al. Br J Surg. 2008 Sep.

Abstract

Background: The feasibility of producing 'biosutures' coated with adipose-derived mesenchymal stem cells (ASCs) was assessed and their effect on colonic anastomoses evaluated.

Methods: Sutures were cultured with ASCs isolated from BDIX rats before analysis by light and scanning electron microscopy. Anastomoses were performed in 40 BDIX rats using either biosutures or conventional sutures. Histopathological features, adhesion formation and anastomotic strength were evaluated.

Results: Sutures were coated with ASCs within 24 h. Anastomoses made with biosutures had a lower adhesion index only during the first week (P = 0.006 at 7 days), but not subsequently. There were no significant differences in anastomotic healing with the two types of suture.

Conclusion: ASC biosutures have no effect on anastomotic healing in rats.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types