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Review
. 2008 Aug;8(9):856-68.
doi: 10.2174/138955708785132774.

Small molecules targeting p53 to improve antitumor therapy

G L Beretta  1 , L Gatti, V Benedetti, P Perego, F Zunino
Affiliations
Review

Small molecules targeting p53 to improve antitumor therapy

G L Beretta et al. Mini Rev Med Chem. 2008 Aug.

Abstract

Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

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