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. 2008 Aug;121(8):702-8.
doi: 10.1016/j.amjmed.2008.03.029.

Incidence of Pseudomonas aeruginosa bacteremia: a population-based study

Majdi N Al-Hasan  1 , John W Wilson, Brian D Lahr, Jeanette E Eckel-Passow, Larry M Baddour
Affiliations

Incidence of Pseudomonas aeruginosa bacteremia: a population-based study

Majdi N Al-Hasan et al. Am J Med. 2008 Aug.

Abstract

Background: The incidence of Pseudomonas aeruginosa bacteremia has not been defined in a population-based investigation.

Methods: We performed a retrospective, population-based incidence study using resources of the Rochester Epidemiology Project of Olmsted County, Minnesota. We identified all Olmsted County residents with P. aeruginosa bacteremia between January 1, 1997, and December 31, 2006, by microbiology records in the only 2 laboratories in the county. Medical records were reviewed to confirm diagnosis, residency status, and clinical characteristics.

Results: Age-adjusted incidence per 100,000 person-years was 10.8 (95% confidence interval [CI], 7.5-14.0) in men and 3.7 (95% CI, 2.2-5.2) in women for total P. aeruginosa bacteremia, and 8.4 (95% CI, 5.5-11.2) in men and 2.5 (95% CI, 1.3-3.8) in women for monomicrobial P. aeruginosa bacteremia. There was no significant change in incidence of total P. aeruginosa bacteremia during the past decade (P=.418). Incidence increased exponentially with age, with a greater magnitude of increase in men compared with women for total and monomicrobial P. aeruginosa bacteremia (P=.007 and P=.015, respectively). In patients with monomicrobial P. aeruginosa bacteremia, the median age was 69 years, and 78.4% of cases were either nosocomial or health care associated. Most patients had multiple comorbid conditions. The urinary tract was the most common primary source of infection. The 28-day all-cause mortality of monomicrobial P. aeruginosa bacteremia was 25.5%. In vitro susceptibility to ciprofloxacin was 95.3%.

Conclusion: To our knowledge, this is the first population-based incidence study of P. aeruginosa bacteremia. The incidence of P. aeruginosa bacteremia has remained stable during the past decade. Fluoroquinolone susceptibility is high among local P. aeruginosa bacteremia isolates.

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Conflict of interest statement

Potential conflicts of interest. MNA, JWW, BDL, JEE, and LMB: No conflict.

Figures

Figure 1
Figure 1
Age- and gender-adjusted incidence of Pseudomonas aeruginosa bacteremia by calendar year
Figure 2
Figure 2
Incidence of total Pseudomonas aeruginosa bacteremia by age group and gender: 1997-2006
Figure 3
Figure 3
a Kaplan-Meier 28-day survival curves of patients with monomicrobial P. aeruginosa bacteremia by Pitt bacteremia score (p=0.045). b Kaplan-Meier 1-year survival curves of patients with monomicrobial P. aeruginosa bacteremia by Pitt bacteremia score (p=0.002).
See this image and copyright information in PMC

References

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    1. US Census Bureau. Olmsted County QuickFacts. http://quickfacts.census.gov/qfd/states/27/27109.html.

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