Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Aug 12;14(2):107-8.
doi: 10.1016/j.ccr.2008.07.008.

Drug-resistant phosphatidylinositol 3-kinase: guidance for the preemptive strike

Peter K Vogt  1
Affiliations
Free article
Comment

Drug-resistant phosphatidylinositol 3-kinase: guidance for the preemptive strike

Peter K Vogt. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Zunder et al. (2008) describe surprising findings from investigating inhibitor-resistant mutations in the affinity pocket of p110 alpha of phosphatidylinositol 3-kinase (PI3K). Information on these critical residues provides a road map for generating novel PI3K inhibitors that can overcome the anticipated resistance mutations.

PubMed Disclaimer

Comment on

MeSH terms

LinkOut - more resources