Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2008 Sep 1;18(17):4872-5.
doi: 10.1016/j.bmcl.2008.07.071. Epub 2008 Jul 24.

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D Hughes  1 , Julian Blagg, David A Price, Simon Bailey, Gary A Decrescenzo, Rajesh V Devraj, Edmund Ellsworth, Yvette M Fobian, Michael E Gibbs, Richard W Gilles, Nigel Greene, Enoch Huang, Teresa Krieger-Burke, Jens Loesel, Travis Wager, Larry Whiteley, Yao Zhang
Affiliations
Comparative Study

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D Hughes et al. Bioorg Med Chem Lett. .

Abstract

Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.

PubMed Disclaimer

Publication types

Substances