ATM breaks into heterochromatin
- PMID: 18691960
- DOI: 10.1016/j.molcel.2008.07.004
ATM breaks into heterochromatin
Abstract
Heterochromatin is refractory to DNA transactions, including repair. In a recent issue of Molecular Cell, Goodarzi et al. (2008) reveal how the central transducing kinase of the DNA damage response relieves this natural barrier by increasing heterochromatic DNA accessibility.
Comment on
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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.Mol Cell. 2008 Jul 25;31(2):167-77. doi: 10.1016/j.molcel.2008.05.017. Mol Cell. 2008. PMID: 18657500
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