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Review
. 2008 Nov 1;7(11):1912-5.
doi: 10.1016/j.dnarep.2008.07.008. Epub 2008 Aug 27.

XPD structure reveals its secrets

Alan R Lehmann  1
Affiliations
Review

XPD structure reveals its secrets

Alan R Lehmann. DNA Repair (Amst). .

Abstract

The XPD protein is central to our understanding of the relationship between NER deficiencies and human disorders. Three recent papers report the crystal structures of XPD from archaea. Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel "Arch" domain. The structures help our understanding of genotype-phenotype relationships in the XPD gene.

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