The nucleotide sequence and evolution of ovine MHC class II B genes: DQB and DRB
- PMID: 1869309
- DOI: 10.1007/BF00211420
The nucleotide sequence and evolution of ovine MHC class II B genes: DQB and DRB
Erratum in
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The nucleotide sequence and evolution of ovine MHC class II B genes: DQB and DRB.Immunogenetics. 1992;35(3):217. doi: 10.1007/BF00185117. Immunogenetics. 1992. PMID: 1537613 No abstract available.
Abstract
The nucleotide sequences of one Ovar-DQB gene, excluding exon 1 and parts of the introns, and one Ovar-DRB pseudogene are presented. The structure of the Ovar-DQB gene is typical of a major histocompatibility complex (MHC) class II B gene and demonstrates considerable sequence similarity with that of humans including such characteristics as the less common polyadenylation signal, ATTAAA. The ovine sequence has a typical 5' acceptor splice signal for exon 5, thus potentially encoding a full length cytoplasmic tail. The Ovar-DRB gene identified in this study was found to be a pseudogene, lacking a defined exon 2 and containing premature termination codons in both exons 3 and 4. The 3' donor splice site of exon 3 is also atypical. A purine-pyrimidine microsatellite repeat, (dC.dA)15, in the 3' region of the pseudogene may be a hotspot for recombination within the ovine DR subregion.
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