doi: 10.1016/j.phymed.2008.06.001.
Epub 2008 Aug 6.
A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity
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- PMID: 18693100
- DOI: 10.1016/j.phymed.2008.06.001
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A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity
Phytomedicine.
2009 Mar.
Abstract
Acetone extract of Elephantopus scaber, an ethnomedicnal plant, reduced the blood glucose levels in streptozotocin-induced diabetic rats significantly. Acute toxicity studies revealed the non-toxic nature of the crude extract. Fractionation of the acetone extract yielded a new steroid, 28Nor-22(R)Witha 2,6,23-trienolide. Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats. This compound can be a useful candidate to treat diabetes.
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