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. 2008 Sep-Oct;10(5):628-31.
doi: 10.1021/cc8001102. Epub 2008 Aug 12.

Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach

Neil Brown  1 , Ge Gao, Machiko Minatoya, Baohan Xie, David Vandervelde, Gerald H Lushington, Jean-Pierre H Perchellet, Elisabeth M Perchellet, Kyle R Crow, Keith R Buszek
Affiliations

Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach

Neil Brown et al. J Comb Chem. 2008 Sep-Oct.
No abstract available

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Figures

Figure 1
Figure 1
Octalactin A.
Scheme 1
Scheme 1
Retrosynthetic Analysis of the Basic Scaffold
Scheme 2
Scheme 2
Scaffold Synthesis via RCM
Scheme 3
Scheme 3
Deprotection and Derivatization of the Scaffold
Scheme 4
Scheme 4
Tertiary Amine Derivatization
Scheme 5
Scheme 5
Amide Derivatization
Scheme 6
Scheme 6
Sulfonamide Derivatization
Scheme 7
Scheme 7
Carbamate Derivatization
Scheme 8
Scheme 8
Urea Derivatization
Scheme 9
Scheme 9
Modification of the Lactam Olefin
Scheme 10
Scheme 10
Facile Synthesis of Nine-Membered Lactam Scaffold
See this image and copyright information in PMC

References

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