Comment
doi: 10.1016/j.devcel.2008.07.012.
Intriguing extracellular regulation of BMP signaling
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- PMID: 18694555
- DOI: 10.1016/j.devcel.2008.07.012
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Comment
Intriguing extracellular regulation of BMP signaling
Dev Cell.
2008 Aug.
Free article
Abstract
Extracellular components of the BMP signaling pathway bind specific partners with high affinity, implying regulation by dedicated protein-protein interactions. In this and other recent issues of Developmental Cell, new results by Ambrosio et al. (and others) suggest, however, that these factors interact in more complex ways to regulate BMP signaling on a fine scale.
Comment on
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Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding.Dev Cell. 2008 May;14(5):739-50. doi: 10.1016/j.devcel.2008.02.017. Dev Cell. 2008. PMID: 18477456
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The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila.Dev Cell. 2008 Jun;14(6):940-53. doi: 10.1016/j.devcel.2008.03.023. Dev Cell. 2008. PMID: 18539121 Free PMC article.
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Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.Dev Cell. 2008 Aug;15(2):248-60. doi: 10.1016/j.devcel.2008.06.013. Dev Cell. 2008. PMID: 18694564 Free PMC article.
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