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Comment
. 2008 Aug 19;105(33):11595-6.
doi: 10.1073/pnas.0806633105. Epub 2008 Aug 11.

Genetic complexity in sickle cell disease

Douglas R Higgs  1 , William G Wood
Affiliations
Comment

Genetic complexity in sickle cell disease

Douglas R Higgs et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Locations of the five SNPs that act as QTL on the level of fetal hemoglobin in adults. They may act directly on the expression of the γ-globin genes or affect the process of erythropoiesis to increase the proportion of F cell production.
See this image and copyright information in PMC

Comment on

References

    1. Pauling L, Itano HA, Singer SJ, Wells IG. Sickle-cell anemia, a molecular disease. Science. 1949;110:543–548. - PubMed
    1. Bunn HF. Pathogenesis and treatment of sickle cell disease. N Engl J Med. 1997;337:762–769. - PubMed
    1. Leikin SL, et al. Mortality in children and adolescents with sickle cell disease. Cooperative Study of Sickle Cell Disease. Pediatrics. 1989;84:500–508. - PubMed
    1. Serjeant GR, Higgs DR, Hambleton IR. Elderly survivors with homozygous sickle cell disease. N Engl J Med. 2007;356:642–643. - PubMed
    1. Higgs DR, et al. The interaction of α-thalassemia and homozygous sickle-cell disease. N Engl J Med. 1982;306:1441–1446. - PubMed