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Comment
. 2008 Sep;128(9):2142-4.
doi: 10.1038/jid.2008.217.

The human papillomavirus type 8 E2 gene encodes a transforming activity sufficient for skin tumor formation in transgenic mice

Margaret McLaughlin-Drubin  1 , Karl Münger
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The human papillomavirus type 8 E2 gene encodes a transforming activity sufficient for skin tumor formation in transgenic mice

Margaret McLaughlin-Drubin et al. J Invest Dermatol. 2008 Sep.
Free article

Abstract

Infections with beta-genus human papillomaviruses (HPVs) have been associated with nonmelanoma skin cancers, particularly in immunocompromised patients and individuals with a rare genetic disease, epidermodysplasia verruciformis (EV). Using a transgenic mouse model, Herbert Pfister's group determined that expression of the HPV8 E2 gene results in skin cancer development and that this process is greatly accelerated by UV irradiation (Pfefferle et al., 2008, this issue).

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