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Review
. 2008 Aug:23:205-11.
doi: 10.1152/physiol.00008.2008.

The Na-K-ATPase and calcium-signaling microdomains

Jiang Tian  1 , Zi-jian Xie
Affiliations
Review

The Na-K-ATPase and calcium-signaling microdomains

Jiang Tian et al. Physiology (Bethesda). 2008 Aug.

Abstract

The Na-K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into transmembrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na-K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na-K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules, including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na+. This review focuses on the unique properties of the Na-K-ATPase and its role in the formation of different calcium-signaling microdomains.

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Figures

FIGURE 1
FIGURE 1
The potential role of Na-K-ATPase in the formation of a junctional calcium-signaling microdomain in renal epithelial cells.
See this image and copyright information in PMC

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