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. 2008 Sep 10;130(36):11836-7.
doi: 10.1021/ja801968f. Epub 2008 Aug 13.

Photoswitched DNA-binding of a photochromic spiropyran

Johanna Andersson  1 , Shiming Li, Per Lincoln, Joakim Andréasson
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Free article

Photoswitched DNA-binding of a photochromic spiropyran

Johanna Andersson et al. J Am Chem Soc. .
Free article

Abstract

The dramatically different DNA-binding properties of the two isomeric forms of a photochromic spiropyran have been demonstrated, enabling photoswitched DNA binding. The closed, UV-absorbing form shows no signs of interaction with DNA. Upon UV exposure the spiropyran is isomerized to the open form that binds to DNA by intercalation. The process is fully reversible as the corresponding dissociation process is induced by visible light.

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