Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Sep;43(3):402-7.
doi: 10.1016/j.cyto.2008.07.017. Epub 2008 Aug 12.

An overview of IL-17 function and signaling

Sarah L Gaffen  1
Affiliations
Review

An overview of IL-17 function and signaling

Sarah L Gaffen. Cytokine. 2008 Sep.

Abstract

Since the discovery of interferons over 50 years ago, efforts to understand the biochemistry, molecular biology and biological activities of cytokines have been intense and rewarding. Although there are several hundred cytokines and receptors currently recognized, they in fact fall into a fairly limited set of subfamilies (reviewed in [Ozaki K, Leonard WJ. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem 2002;277:29355-58 [1]; Shen F, Gaffen SL. Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy. Cytokine 2008;41:92-104 [2]). Within these families (and in some cases even outside them), cytokines share many structural and functional features that have provided a framework for understanding their biological activities and signal transduction mechanisms. This review will focus on interleukin (IL)-17, the founding member of the newest subclass of cytokines, which has received considerable attention in the last several years due to its central role in the Th17 system.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Th cell differentiation
See this image and copyright information in PMC

References

    1. Ozaki K, Leonard WJ. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem. 2002;277:29355–29358. - PubMed
    1. Shen F, Gaffen SL. Structure-function relationships in the IL-17 receptor: Implications for signal transduction and therapy. Cytokine. 2008;41:92–104. - PMC - PubMed
    1. Rouvier E, Luciani M-F, Mattei M-G, Denizot F, Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a Herpesvirus Saimiri gene. J. Immunol. 1993;150:5445–5456. - PubMed
    1. Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ. Cutting Edge: Human IL-17: A novel cytokine derived from T cells. J. Immunol. 1995;155:5483–5486. - PubMed
    1. Yao Z, Fanslow WC, Seldin MF, Rousseau A-M, Painter SL, Comeau MR, Cohen JI, Spriggs MK. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995;3:811–821. - PubMed

Publication types

MeSH terms

LinkOut - more resources