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. 2008 Oct;10(5):488-94.
doi: 10.1016/j.jfms.2008.05.002. Epub 2008 Aug 15.

Insulin glargine has a long duration of effect following administration either once daily or twice daily in divided doses in healthy cats

Rhett D Marshall  1 , Jacquie S Rand, John M Morton
Affiliations

Insulin glargine has a long duration of effect following administration either once daily or twice daily in divided doses in healthy cats

Rhett D Marshall et al. J Feline Med Surg. 2008 Oct.

Abstract

The pharmacological effects of glargine administered once or twice daily were compared in six healthy cats. A two-way crossover study was performed with insulin and glucose concentrations measured following subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/kg, repeated after 12h). Nadir glucose concentration and mean daily glucose concentration did not differ significantly following insulin administration once daily or twice daily in divided doses. Time to reach last glucose nadir differed, with longer intervals occurring following twice daily dosing. Blood glucose failed to return to baseline concentration by 24h in three of six cats in each treatment group. Insulin variables were not significantly different following once or twice daily dosing. This study in healthy cats demonstrates that glargine has a long duration of action with carry-over effects to the next day likely, regardless of dosing regimen. A study in diabetic cats is required to determine the best dosing regimen.

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Figures

Fig 1.
Fig 1.
Mean plasma glucose concentrations (and standard errors of means) after subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/kg repeated after 12 h) in a two-way crossover study in six healthy cats.
Fig 2.
Fig 2.
Mean plasma insulin concentrations (and standard errors of means) after subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/kg repeated after 12 h) in a two-way crossover study in six healthy cats.
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