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. 2008 Aug;25(8):353-7.
doi: 10.1007/s10815-008-9237-y. Epub 2008 Aug 14.

Interval double transfer improves treatment success in patients with repeated IVF/ET failures

B Almog  1 , I Levin, I Wagman, R Kapustiansky, T Schwartz, N Mey-Raz, A Amit, F Azem
Affiliations

Interval double transfer improves treatment success in patients with repeated IVF/ET failures

B Almog et al. J Assist Reprod Genet. 2008 Aug.

Abstract

Purpose: To examine whether double transfer of embryos on day 2-3 and on day 5 after ovum pick-up (OPU) improves IVF/ET success rates in patients with multiple consecutive IVF failures

Methods: Consecutive IVF failures patients (7.6 +/- 0.5) undergoing IVF/ET cycles were treated with interval double transfer on day 2-3 and on day 5 after OPU. Matched patients, that had embryos transferred only once on day 2 or 3 served as controls.

Results: Baseline and cycle characteristics were similar in the study group and controls. The total pregnancy rate was 44.6% in the study group and 24.2% in the controls (p = 0.001), and the clinical pregnancy rates were 38.5% and 19.6%, respectively (p = 0.001).

Conclusions: Patients with multiple consecutive IVF/ET failures, treated with the interval double transfer approach had significantly improved cycle success rates compared with regular day 2 or 3 embryo transfer protocol.

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