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. 2008 Jul;9(6):440-4.
doi: 10.1111/j.1468-1293.2008.00576.x.

Effect of early initiation of highly active antiretroviral therapy on CD4 cell count and HIV-RNA viral load trends within 24 months of the onset of acute retroviral syndrome

N Voirin  1 , J-P Routy, D Smith, D Baratin, C Trépo, L Cotte, J-L Touraine, J-M Livrozet, D A Cooper, J Ritter, P André, P Vanhems
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Free article

Effect of early initiation of highly active antiretroviral therapy on CD4 cell count and HIV-RNA viral load trends within 24 months of the onset of acute retroviral syndrome

N Voirin et al. HIV Med. 2008 Jul.
Free article

Abstract

Objectives: The effect of starting highly active antiretroviral therapy (HAART) early after the onset of acute retroviral syndrome (ARS) on CD4 and HIV-RNA trends was studied over a 2-year follow-up period.

Methods: Four groups of HIV-infected patients stratified according to the time interval from ARS onset to HAART initiation and a control group of untreated patients were compared.

Results: The results indicated that the earlier the start of HAART, the faster was the rate of CD4 increase and HIV-RNA decrease. However, this difference did not seem to persist at 24 months.

Conclusions: The optimal treatment strategy for HIV-infected patients needs to be explored further.

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