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Randomized Controlled Trial
. 2008 Aug 15;27(1):29.
doi: 10.1186/1756-9966-27-29.

Radioguided breast surgery for occult lesion localization - correlation between two methods

Marcelo Moreno  1 , Janete Eunice Wiltgen, Benito Bodanese, Ricardo Ludwig Schmitt, Bianca Gutfilen, Lea Mirian Barbosa da Fonseca
Affiliations
Randomized Controlled Trial

Radioguided breast surgery for occult lesion localization - correlation between two methods

Marcelo Moreno et al. J Exp Clin Cancer Res. .

Abstract

Background: The detection of sub-clinical breast lesions has increased with screening mammography. Biopsy techniques can offer precision and agility in its execution, as well as patient comfort. This trial compares radioguided occult lesion localization (ROLL) and wire-guided localization (WL) of breast lesions. We investigate if a procedure at the ambulatorial level (ROLL) could lead to a better aesthetic result and less postoperative pain. In addition, we intend to demonstrate the efficacy of radioguided localization and removal of occult breast lesions using radiopharmaceuticals injected directly into the lesions and correlate radiological and histopathological findings.

Methods: One hundred and twenty patients were randomized into two groups (59 WL and 61 ROLL). The patients were requested to score the cosmetic appearance of their breast after surgery, and a numerical rating scale was used to measure pain on the first postoperative day. Clearance margins were considered at > or = 10 mm for invasive cancer, > or = 5 mm for ductal carcinoma in situ, and > or = 1 mm for benign disease. Patients were subsequently treated according to the definitive histological result. When appropriate, different statistical tests were used in order to test the significance between the two groups, considering a P value < 0.05 as statistically significant.

Results: WL and ROLL located all the occult breast lesions successfully. In the ROLL group, the specimen volume was smaller and there were more cases with clear margins (P < 0.05). There were significant differences in mean time of hospital stay between WL and ROLL (21.42 vs. 2.56 hours), but not in operative time (39.4 vs. 29.9 minutes). There were significant differences in the subjective ease of the procedures as rated by the patients (cosmetic outcomes and postoperative pain).

Conclusion: ROLL is an effective method for the excision of non-palpable breast lesions. It enables more careful planning of the cutaneous incision, leading to better aesthetic results, less postoperative symptoms, and smaller volumes of excised tissue.

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Figures

Figure 1
Figure 1
Lateral (A) and front (B) view planar scintigraphic images to check the radiographic correlation of a breast lesion (arrow).
See this image and copyright information in PMC

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References

    1. Anderson BO, Braun S, Carlson RW, Gralow JR, Lagios MD, Lehman C, Schwartsmann G, Vargas HI. Overview of breast health care guidelines for countries with limited resources. Breast J. 2003;9:S42–S50. doi: 10.1046/j.1524-4741.9.s2.3.x. - DOI - PubMed
    1. Kopans DB. In: Imaging-guided needle placement for biopsy and the preoperative localization of clinically occult lesions. Kopans DB, editor. Breast Imaging, United States of America, LIPPINCOTT Williams & Wilkins; 1997. pp. 637–720.
    1. Moss HA, Barter SJ, Nayagam M, Lawrence D, Pittan M. The use of carbon suspension as an adjunct to wire localization of impalpable breast lesions. Clin Radiol. 2002;57:937–944. doi: 10.1053/crad.2002.0994. - DOI - PubMed
    1. Gray RJ, Salud C, Nguyen K, Dauway E, Friedland J, Berman C, Peltz E, Whitehead G, Cox CE. Randomized prospective evaluation of a novel technique for biopsy or lumpectomy of nonpalpable breast lesions: radioactive seed versus wire localization. Ann Surg Oncol. 2001;9:711–715. doi: 10.1007/s10434-001-0711-3. - DOI - PubMed
    1. Rampaul RS, Bagnall M, Burrel H, Pinsder SE, Evans AJ, Macmillan RD. Randomized clinical trial comparing radioisotope occult lesion localization and wire-guided excision for biopsy of occult breast lesions. Br J Surg. 2004;91:1575–1577. doi: 10.1002/bjs.4801. - DOI - PubMed

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