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. 2008 Nov;89(2):222-6.
doi: 10.1016/j.radonc.2008.07.018. Epub 2008 Aug 14.

Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

Pedro Carlos Lara  1 , Marta Lloret, Bernardino Clavo, Rosa Maria Apolinario, Elisa Bordón, Agustin Rey, Orlando Falcón, Ana Ruiz Alonso, Claus Belka
Affiliations

Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

Pedro Carlos Lara et al. Radiother Oncol. 2008 Nov.

Abstract

Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.

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