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. 2008 Oct 30;164(1):73-6.
doi: 10.1016/j.pscychresns.2007.12.010. Epub 2008 Aug 15.

The MAO-A genotype does not modulate resting brain metabolism in adults

Nelly Alia-Klein  1 , Aarti Kriplani, Kith Pradhan, Jim Yeming Ma, Jean Logan, Benjamin Williams, Ian W Craig, Frank Telang, Dardo Tomasi, Rita Z Goldstein, Gene-Jack Wang, Nora D Volkow, Joanna S Fowler
Affiliations

The MAO-A genotype does not modulate resting brain metabolism in adults

Nelly Alia-Klein et al. Psychiatry Res. .

Abstract

Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.

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Figures

Fig. 1
Fig. 1
Absolute Glucose Metabolism at Rest in the low and high MAO-A Genotype Groups. From manually drawn bilateral (averaged) ROI in dorsolateral prefrontal cortex (DLPC), medial prefrontal cortex (MPC), lateral orbitofrontal cortex (OFC), anterior cingulate gyrus (ACG), parietal cortex (PRT), medial and lateral temporal cortices (TMP), the visual cortex (VIS), insula (INS), thalamus (THL) and amygdala (AMYG). Error bar represent standard deviation.
See this image and copyright information in PMC

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