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Comparative Study
. 2008 Aug:14 Suppl 4:27-30.

Investigation of immunogenic T-cell epitopes in SARS virus nucleocapsid protein and their role in the prevention and treatment of SARS infection

Y K Cheung  1 , S C S Cheng, F W Y Sin, K T Chan, Y Xie
Affiliations
  • PMID: 18708671
Free article
Comparative Study

Investigation of immunogenic T-cell epitopes in SARS virus nucleocapsid protein and their role in the prevention and treatment of SARS infection

Y K Cheung et al. Hong Kong Med J. 2008 Aug.
Free article

Abstract

1. A novel HLA-A2.1-specific SARS coronavirus (SARS-CoV) nucleocapsid (N) protein epitope (N220-N228 LALLLLDRL) able to activate cytotoxic T cells in vitro has been identified. 2. When used with a single-chain-trimer system, the SARS-CoV N protein epitope (N220-N228 LALLLLDRL) can stimulate a cytotoxic T-cell response against N-protein expressing cells in the HLA-A2.1K(b) transgenic mouse model.

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