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Comment
. 2008 Sep;74(5):551-3.
doi: 10.1038/ki.2008.290.

Blocking of angiotensin II is more than blocking of transforming growth factor-beta

Christoph Daniel  1
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Free article
Comment

Blocking of angiotensin II is more than blocking of transforming growth factor-beta

Christoph Daniel. Kidney Int. 2008 Sep.
Free article

Abstract

Fibrosis is a common feature of chronic kidney diseases that is mediated by matrix-producing myofibroblasts. One potential origin of myofibroblasts is epithelial-mesenchymal transition (EMT) of tubuloepithelial cells. Transforming growth factor-beta (TGF-beta) is a key factor inducing EMT. Carvajal et al. demonstrate that angiotensin II induces EMT by classical stimulation of TGF-beta and also by a TGF-beta-independent pathway, both signaling via Smad molecules. Therefore, blockade of angiotensin II is more than lowering of blood pressure and inhibition of TGF-beta stimulation.

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