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. 2008 Nov 15;112(10):4247-9.
doi: 10.1182/blood-2008-05-157974. Epub 2008 Aug 18.

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

Qing Lan  1 , Unhee Lim, Chin-San Liu, Stephanie J Weinstein, Stephen Chanock, Matthew R Bonner, Jarmo Virtamo, Demetrius Albanes, Nathaniel Rothman
Affiliations

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

Qing Lan et al. Blood. .

Abstract

Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood cell DNA from healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a dose-response relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; P(trend) = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; P(trend) = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL.

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References

    1. Chan DC. Mitochondria: dynamic organelles in disease, aging, and development. Cell. 2006;125:1241–1252. - PubMed
    1. Croteau DL, Bohr VA. Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem. 1997;272:25409–25412. - PubMed
    1. Clayton DA. Transcription of the mammalian mitochondrial genome. Annu Rev Biochem. 1984;53:573–594. - PubMed
    1. Lee HC, Lu CY, Fahn HJ, Wei YH. Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Lett. 1998;441:292–296. - PubMed
    1. Renis M, Cantatore P, Loguercio PP, Fracasso F, Gadaleta MN. Content of mitochondrial DNA and of three mitochondrial RNAs in developing and adult rat cerebellum. J Neurochem. 1989;52:750–754. - PubMed

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