Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Nov;6(11):864-70.
doi: 10.1038/nrmicro1988. Epub 2008 Aug 19.

What really happens to dendritic cells during malaria?

Michelle N Wykes  1 , Michael F Good
Affiliations
Review

What really happens to dendritic cells during malaria?

Michelle N Wykes et al. Nat Rev Microbiol. 2008 Nov.

Abstract

As dendritic cells (DCs) initiate all adaptive and some innate immune responses, it is not surprising that DC function during malaria is the subject of intensive investigations. However, the results of these investigations have so far been controversial. Here, we discuss various aspects of these studies, including the influence of the species and strain of Plasmodium on DC function, the effects of Plasmodium infection on the activation of CD8(+) T cells by DCs, the effects of haemozoin and the effects of Plasmodium infections on DC Toll-like-receptor signalling.

PubMed Disclaimer

References

    1. J Exp Med. 2005 Jan 3;201(1):19-25 - PubMed
    1. J Immunol. 1996 Apr 1;156(7):2510-6 - PubMed
    1. Science. 1996 Jun 7;272(5267):1502-4 - PubMed
    1. Infect Immun. 1998 Oct;66(10):4783-7 - PubMed
    1. Infect Immun. 2005 Apr;73(4):2478-85 - PubMed

LinkOut - more resources