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. 1991;15(2):241-7.
doi: 10.1016/0278-5846(91)90087-h.

Deuterium-labelled p-tyramine challenge test and phenolsulfotransferase activity in depressed patients--failure to replicate decreased p-tyramine conjugation in depression

B A Davis  1 , A A Boulton, P H Yu, D A Durden, R C Bowen, D L Keegan, S Blackshaw, C D'Arcy, A J Remillard, N Dayal, et al.
Affiliations

Deuterium-labelled p-tyramine challenge test and phenolsulfotransferase activity in depressed patients--failure to replicate decreased p-tyramine conjugation in depression

B A Davis et al. Prog Neuropsychopharmacol Biol Psychiatry. 1991.

Abstract

1. Depressed and normal subjects were challenged with deuterium-labelled p-tyramine and urine was collected for 3 h. 2. Urinary excretion of conjugated p-tyramine was not significantly different between normal, melancholic and non-melancholic depressed subjects. 3. Platelet phenolsulfotransferase activity to p-tyramine (p less than 0.05) and to phenol (p less than 0.005) were significantly lower in the depressed patients.

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