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Review
. 2008 Dec 19;283(51):35305-9.
doi: 10.1074/jbc.R800044200. Epub 2008 Aug 18.

Some assembly required: putting the epithelial sodium channel together

Michael B Butterworth  1 , Ora A Weisz, John P Johnson
Affiliations
Review

Some assembly required: putting the epithelial sodium channel together

Michael B Butterworth et al. J Biol Chem. .
No abstract available

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Figures

FIGURE 1.
FIGURE 1.
Models of non-coordinate regulation of ENaC by post-ER assembly and proteolysis. In Model 1, assembly of ENaC heterotrimers is not co-translational: partial ENaC subunits or partial channels in post-ER compartments can combine with induced subunits to form fully active channels that traffic to cell surface. In Model 2, physiological stimuli cause uncleaved channels at or near the apical membrane to be either cleaved or replaced by fully mature cleaved channels (yellow). Evidence for both of these models is presented in the text.
FIGURE 2.
FIGURE 2.
Model for non-coordinate regulation by subunit remodeling. In this model, channels composed of two subunits exist and are capable of remodeling at the membrane or in endocytic compartments. Alternatively, non-trimeric channels are trafficked back to the Golgi (potentially via the retromer complex), where they would disassemble to recombine with newly synthesized subunits. Newly assembled, fully active heterotrimeric channels would then traffic to the apical membrane. Evidence for this speculative model is discussed in the text.
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