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Randomized Controlled Trial
. 2008 Sep;107(3):1041-4.
doi: 10.1213/ane.0b013e31817f1e4a.

Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery

Masanori Yamauchi  1 , Makoto Asano, Masanori Watanabe, Soushi Iwasaki, Shingo Furuse, Akiyoshi Namiki
Affiliations
Randomized Controlled Trial

Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery

Masanori Yamauchi et al. Anesth Analg. 2008 Sep.

Abstract

Background: The effects of fentanyl with ketamine for postoperative pain are unknown. We investigated the adjuvant effects of ketamine for fentanyl patient-controlled analgesia.

Methods: Cervical and lumbar spine surgery patients were divided into three groups: ketamine 1 mg/kg followed by 42 and 83 microg x kg(-1) x h(-1) in ketamine-1 and ketamine-2 group, respectively, and a control group. Postoperative patient-controlled analgesia fentanyl was administered with a background infusion.

Results: Pain scores and analgesia requirement in the ketamine-2 group were significantly lower than those of the control group after cervical surgery. Ketamine partially improved the analgesic effects of fentanyl after lumbar surgery.

Conclusion: Small-dose ketamine improved the analgesic effects of fentanyl after cervical surgery.

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