Comparative Study
doi: 10.1007/BF01317871.
Individual translational efficiencies of SV40 and cellular mRNAs
- PMID: 187145
- DOI: 10.1007/BF01317871
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Comparative Study
Individual translational efficiencies of SV40 and cellular mRNAs
Arch Virol.
1976.
Abstract
The technique of selective inhibition of peptide chain initiation by growth medium hypertonicity was adapted for cell monolayer cultures and applied to a study of protein synthesis in SV40 infected BSC-1 cells. The translational efficiences for individual peptide chain initiation sites on SV40 mRNAs were determined and compared to those for cellular mRNA species under conditions of a reduced rate of peptide chain initiation. The SV40 mRNAs show different translational efficiences. The results indicate that the synthesis of the SV40 proteins VP1, 2 and 3 are initiated independently and with different rates on viral mRNA(s). It is proposed, therefore, that VP2 is not a precursor for VP3.
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