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Comparative Study
. 2008;29(4):327-32.

Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS study

A Longatto-Filho  1 , C Roteli-Martins, L Hammes, D Etlinger, S M Miranda Pereira, M Erzen, M Branca, P Naud, S F M Derchain, L O Sarian, J Matos, R Gontijo, T Lima, M Y S Maeda, S Tatti, S Syrjänen, K Syrjänen
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  • PMID: 18714563
Comparative Study

Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS study

A Longatto-Filho et al. Eur J Gynaecol Oncol. 2008.

Abstract

Purpose: To compare Hybrid Capture II (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples.

Methods: Patients were submitted to Pap smears, visual inspection with acetic acid (VIA) and HC2 for hr-HPV.

Results: A total of 1,081 HC2 tests for HR-HPV were performed: 770 (71.2%) samples were collected by a physician and 311 (28.8%) were self-collected by the patients. In detecting any cervical lesion, the sensitivity of HC2 collected by a physician was higher (92.86%) than that (37.5%) in the self-sampling group. Negative predictive value (NPV) was high for both, 99.69% and 93.75%, respectively. Using the CIN2 cutoff, performance of HC2 was significantly improved: 92.9% and 62.5%, respectively. HC2 specificity for any cervical lesion and for CIN2 or higher were close to 90% in both groups.

Conclusions: Self-sampled HPV testing is a powerful option to increase the detection of cervical lesions in women segregated from prevention programs.

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