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Review
. 2008 Nov;28(6):677-84.
doi: 10.1007/s10875-008-9242-z. Epub 2008 Aug 21.

T regulatory cells in autoimmune diabetes: past challenges, future prospects

Jeffrey A Bluestone  1 , Qizhi Tang, Caitlin E Sedwick
Affiliations
Review

T regulatory cells in autoimmune diabetes: past challenges, future prospects

Jeffrey A Bluestone et al. J Clin Immunol. 2008 Nov.

Abstract

Introduction: Accumulating evidence suggests that defective regulation is an essential underlying cause of autoimmunity. The development of type 1 diabetes in the NOD mouse strain it is a complex process that depends on a fine balance between pathogenic and regulatory pathways.

Discussion: We have utilized a series of transgenic and knockout mice to determine the relative importance of regulatory T cells and negative regulatory receptors on the development and progression of type 1 diabetes.

Conclusion: This review will focus on the origins and function of Treg in peripheral self-tolerance. We will summarize the role of Treg in preventing autoimmune diseases, with a particular focus on Type 1 Diabetes (T1D), and discuss the prospects for Treg-based therapies for autoimmune diseases.

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