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. 2008 Aug 15;7(16):2493-9.
doi: 10.4161/cc.7.16.6452. Epub 2008 Aug 17.

Functional integration of microRNAs into oncogenic and tumor suppressor pathways

Craig D Lotterman  1 , Oliver A Kent, Joshua T Mendell
Affiliations

Functional integration of microRNAs into oncogenic and tumor suppressor pathways

Craig D Lotterman et al. Cell Cycle. .

Abstract

A large body of evidence has documented abnormal microRNA (miRNA) expression patterns in diverse human malignancies. Given that miRNA expression is tightly regulated during development and cellular differentiation, aberrant miRNA expression in cancer cells is likely to be in part a consequence of the loss of normal cellular identity that accompanies malignant transformation. Nevertheless, it is now clear that miRNAs function as critical effectors of several canonical oncogenic and tumor suppressor pathways, including those controlled by Myc and p53. Gain- and loss-of-function of these factors in cancer cells contributes to miRNA dysregulation, directly influencing neoplastic phenotypes including cellular proliferation and apoptosis.

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Figures

Figure 1
Figure 1
Functional integration of miRNAs into oncogenic and tumor suppressor pathways. Transcription factors including Myc (A), the AML1-ETO fusion oncoprotein (B), NF-κB (C), Twist (D), and p53 (E) directly activate and repress miRNA expression to influence cellular phenotypes such as proliferation, apoptosis, angiogenesis, and metastasis.
See this image and copyright information in PMC

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