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Editorial
. 2008 Sep 1;7(17):2615-8.
doi: 10.4161/cc.7.17.6626. Epub 2008 Sep 16.

Cancer and aging: more puzzles, more promises?

Mikhail V Blagosklonny, Judith Campisi
Free article
Editorial

Cancer and aging: more puzzles, more promises?

Mikhail V Blagosklonny et al. Cell Cycle. .
Free article

Abstract

In this issue of Cell Cycle, a new paper shows that metformin, an oral antidiabetic drug that activates AMP-activated protein kinase, prolongs both mean and maximal life span and prevents reproductive aging of female mice. Unexpectedly, metformin did not decrease the incidence of cancer in this mice strain. Here, we discuss the relationship between aging and cancer, the mechanism of metformin action, and the prospects of using this compound for life span extension in humans.

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  • Metformin slows down aging and extends life span of female SHR mice.
    Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Yurova MV, Kovalenko IG, Poroshina TE, Semenchenko AV. Anisimov VN, et al. Cell Cycle. 2008 Sep 1;7(17):2769-73. doi: 10.4161/cc.7.17.6625. Epub 2008 Sep 11. Cell Cycle. 2008. PMID: 18728386

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