Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Mar;129(3):297-301.
doi: 10.1080/00016480802225884.

Overexpression of thymic stromal lymphopoietin in allergic rhinitis

Zhonglin Mou  1 , Jiahong Xia, Yenong Tan, Xiangdong Wang, Yuan Zhang, Bing Zhou, Huabin Li, Demin Han
Affiliations

Overexpression of thymic stromal lymphopoietin in allergic rhinitis

Zhonglin Mou et al. Acta Otolaryngol. 2009 Mar.

Abstract

Conclusion: Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR.

Objective: To evaluate the possible role of TSLP in the pathogenesis of AR.

Patients and methods: We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA).

Results: TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P<0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P<0.05).

PubMed Disclaimer

Publication types

LinkOut - more resources