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. 2008 Nov;341(11):708-13.
doi: 10.1002/ardp.200800011.

Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones)

Julieta Coro  1 , Susan Little, Vanessa Yardley, Margarita Suárez, Hortensia Rodríguez, Nazario Martín, Rolando Perez-Pineiro
Affiliations

Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones)

Julieta Coro et al. Arch Pharm (Weinheim). 2008 Nov.

Abstract

The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.

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