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Randomized Controlled Trial
. 2008 Sep;139(3):414-20.
doi: 10.1016/j.otohns.2008.06.003.

Double-blind, placebo-controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux

Oliver Reichel  1 , Holger Dressel, Katrin Wiederänders, Wolfgang J Issing
Affiliations
Randomized Controlled Trial

Double-blind, placebo-controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux

Oliver Reichel et al. Otolaryngol Head Neck Surg. 2008 Sep.

Abstract

Objective: To determine the efficacy of proton pump inhibitor (PPI) therapy with esomeprazole on symptoms and signs associated with laryngopharyngeal reflux (LPR).

Study design and methods: Prospective, double-blind, randomized, placebo-controlled study. Sixty-two patients with a reflux finding score (RFS)>7 and a reflux symptom index (RSI)>13 were enrolled and received either esomeprazole 20 mg twice daily or placebo for three months. RSI and RFS were assessed at baseline, after six weeks, and after three months.

Results: Reductions of total RSI and RFS as well as of several subscores were significantly higher in the treatment group compared to placebo after three months (P<0.05 each). The difference between study groups was most pronounced for posterior commissure hypertrophy (P<0.01).

Conclusion: In the treatment of LPR-related symptoms a high placebo effect can be observed. However, compared to control, twice-daily PPI treatment for three months demonstrated a significantly greater improvement in laryngeal appearance and LPR symptoms.

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Comment in

  • [What happened to reflux laryngitis?].
    Müller-Lissner S. Müller-Lissner S. Z Gastroenterol. 2008 Dec;46(12):1404-5. doi: 10.1055/s-2008-1027869. Epub 2008 Dec 3. Z Gastroenterol. 2008. PMID: 19053010 German. No abstract available.

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