Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Nov 25;176(2-3):151-64.
doi: 10.1016/j.cbi.2008.07.007. Epub 2008 Aug 3.

The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines

Federico Buonanno  1 , Luana Quassinti, Massimo Bramucci, Consuelo Amantini, Roberta Lucciarini, Giorgio Santoni, Hideo Iio, Claudio Ortenzi
Affiliations

The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines

Federico Buonanno et al. Chem Biol Interact. .

Abstract

Climacostol (5-(Z)-non-2-enyl-benzene-1,3-diol) is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum virens and belongs to the group of resorcinolic lipids, compounds that show antimicrobial, antiparasitic and antitumor activities. We investigated the cytotoxic activity of the chemically synthesized toxin on: (1) human tumor squamous carcinoma A431 cells, (2) human promyelocytic leukaemia HL60 cells, and (3) human non-tumor endothelial EA.hy926 cells. The results showed that climacostol effectively inhibited the growth of tumor cell lines in a dose-dependent manner by inducing programmed cell death, with non-tumor cells proving significantly more resistant to the toxin.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources