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. 2008 Aug 21;15(9):618-24.
doi: 10.1101/lm.1028008. Print 2008 Sep.

The consolidation of object and context recognition memory involve different regions of the temporal lobe

Israela Balderas  1 , Carlos J Rodriguez-Ortiz, Paloma Salgado-Tonda, Julio Chavez-Hurtado, James L McGaugh, Federico Bermudez-Rattoni
Affiliations

The consolidation of object and context recognition memory involve different regions of the temporal lobe

Israela Balderas et al. Learn Mem. .

Abstract

These experiments investigated the involvement of several temporal lobe regions in consolidation of recognition memory. Anisomycin, a protein synthesis inhibitor, was infused into the hippocampus, perirhinal cortex, insular cortex, or basolateral amygdala of rats immediately after the sample phase of object or object-in-context recognition memory training. Anisomycin infused into perirhinal or insular cortices blocked long-term (24 h), but not short-term (90 min) object recognition memory. Infusions into the hippocampus or amygdala did not impair object recognition memory. Anisomycin infused into the hippocampus blocked long-term, but not short-term object-in-context recognition memory, whereas infusions administered into the perirhinal cortex, insular cortex, or amygdala did not affect object-in-context recognition memory. These results clearly indicate that distinct regions of the temporal lobe are differentially involved in long-term object and object-in-context recognition memory. Whereas perirhinal and insular cortices are required for consolidation of familiar objects, the hippocampus is necessary for consolidation of contextual information of recognition memory. Altogether, these results suggest that temporal lobe structures are differentially involved in recognition memory consolidation.

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Figures

Figure 1.
Figure 1.
Protein synthesis in the cortex is required for long-term object recognition memory. (A) Schematic representation of the behavioral protocol used. 90 min (STM), 24 h (LTM). (B) Recognition indexes on object recognition memory test. Two-way ANOVA for short-term memory (STM) groups showed no differences. Anisomycin (ANI), vehicle (VEH), perirhinal cortex (PRH), insular cortex (IC), hippocampus (HIP), basolateral amygdala (BLA). Two-way ANOVA for LTM showed significant differences between groups; Fisher’s post hoc test revealed that the groups infused with ANI into PRH or IC were different from all the vehicle control groups. ** P < 0.01.
Figure 2.
Figure 2.
Protein synthesis in the hippocampus is required for long-term object-in-context recognition memory. (A) Schematic representation of the behavioral protocol used. 90 min (STM), 24 h (LTM). (B) Recognition indexes on object-in-context recognition memory test. Two-way ANOVA for STM showed no differences between groups. Abbreviations are as in Figure 1. Two-way ANOVA for LTM showed significant differences between groups; Fisher’s post hoc test revealed that the HIP-ANI group was different from the other groups (P < 0.05), except with the BLA-ANI group. ** P < 0.01 vs. HIP-VEH.
Figure 3.
Figure 3.
Representative photographs of infusion sites, the arrows point to the needle tips; abbreviations as in Figure 1.
See this image and copyright information in PMC

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