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Comment
. 2008 Aug 22;134(4):569-71.
doi: 10.1016/j.cell.2008.08.010.

Linking retroelements to autoimmunity

Vijay G Bhoj  1 , Zhijian J Chen
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Linking retroelements to autoimmunity

Vijay G Bhoj et al. Cell. .
Free article

Abstract

In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

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