A tale of too many centrosomes
- PMID: 18724931
- DOI: 10.1016/j.cell.2008.08.007
A tale of too many centrosomes
Abstract
Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of aneuploidy, a hallmark of many cancer cells. Several recent studies (Basto et al., 2008; Kwon et al., 2008; Yang et al., 2008) reveal the importance of mechanisms that protect against the consequences of harboring too many centrosomes.
Comment on
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Centrosome amplification can initiate tumorigenesis in flies.Cell. 2008 Jun 13;133(6):1032-42. doi: 10.1016/j.cell.2008.05.039. Cell. 2008. PMID: 18555779 Free PMC article.
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