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. 1991 Mar 26;195(2):305-6.
doi: 10.1016/0014-2999(91)90552-2.

Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo

F A Le Noble  1 , J W Hekking, H W Van Straaten, D W Slaaf, H A Struyker Boudier
Affiliations

Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo

F A Le Noble et al. Eur J Pharmacol. .

Abstract

Angiotensin II was applied daily in doses of 67 or 670 ng to a section of the chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs. During this one-week period, it caused a significant, dose-dependent increase in the vascular density index. The increase obtained with 670 ng daily was comparable to that after daily administration of 1.7 micrograms adenosine, a known stimulator of angiogenesis. The data suggest a possible role for angiotensin II as a mediator of vascular growth.

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