doi: 10.1016/0014-2999(91)90428-s.
Endothelial cells modulate the vasoinhibitory effect of NKY-722, a Ca2+ channel antagonist, in canine mesenteric arteries
Affiliations
- PMID: 1874286
- DOI: 10.1016/0014-2999(91)90428-s
Item in Clipboard
Endothelial cells modulate the vasoinhibitory effect of NKY-722, a Ca2+ channel antagonist, in canine mesenteric arteries
Eur J Pharmacol.
.
Abstract
Modulation of the vasoinhibitory effect of NKY-722 by vascular endothelial cells was studied in canine mesenteric arteries. A high concentration of NKY-722 accumulated in the endothelium-intact arteries and its accumulation in endothelium-removed arteries was significantly less. The vasoinhibitory effect of NKY-722 in endothelium-intact arteries was significantly weaker than that in endothelium-removed arteries. These results suggest that endothelial cells can attenuate the vasoinhibitory effect of NKY-722.
Similar articles
-
Effect of accumulation of NKY-722, a water-soluble vasoselective Ca++ antagonist, on KCl-induced contraction in isolated canine mesenteric arteries.J Pharmacol Exp Ther. 1991 Aug;258(2):676-80. J Pharmacol Exp Ther. 1991. PMID: 1865364
-
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the responses of isolated canine arteries.Arzneimittelforschung. 1995 Aug;45(8):831-5. Arzneimittelforschung. 1995. PMID: 7575741
-
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the endothelium-independent and endothelium-dependent contraction in isolated canine cerebral arteries.Arzneimittelforschung. 1996 Jul;46(7):663-6. Arzneimittelforschung. 1996. PMID: 8842332
-
Role of a third generation calcium antagonist in the management of hypertension.Drugs. 1999;57 Suppl 1:1-10. doi: 10.2165/00003495-199957001-00001. Drugs. 1999. PMID: 10529076 Review.
-
Mode of action of calcium antagonists: voltage-dependence and kinetics of drug-receptor interaction.Pharmacol Toxicol. 1989 Jul;65(1):1-8. doi: 10.1111/j.1600-0773.1989.tb01116.x. Pharmacol Toxicol. 1989. PMID: 2550920 Review. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
