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. 1991 Apr 17;196(2):197-9.
doi: 10.1016/0014-2999(91)90428-s.

Endothelial cells modulate the vasoinhibitory effect of NKY-722, a Ca2+ channel antagonist, in canine mesenteric arteries

H Shimaji  1 , H Shirahase, M Kanda, S Osumi, K Kurahashi
Affiliations

Endothelial cells modulate the vasoinhibitory effect of NKY-722, a Ca2+ channel antagonist, in canine mesenteric arteries

H Shimaji et al. Eur J Pharmacol. .

Abstract

Modulation of the vasoinhibitory effect of NKY-722 by vascular endothelial cells was studied in canine mesenteric arteries. A high concentration of NKY-722 accumulated in the endothelium-intact arteries and its accumulation in endothelium-removed arteries was significantly less. The vasoinhibitory effect of NKY-722 in endothelium-intact arteries was significantly weaker than that in endothelium-removed arteries. These results suggest that endothelial cells can attenuate the vasoinhibitory effect of NKY-722.

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