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Comparative Study
. 2008 Sep 12;22(14):1880-2.
doi: 10.1097/QAD.0b013e32830fbdbc.

HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors

Véronique Avettand-Fenoel  1 , Thierry Prazuck, Laurent Hocqueloux, Adeline Melard, Christophe Michau, Rémy Kerdraon, Eric Agoute, Christine Rouzioux
Affiliations
Comparative Study

HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors

Véronique Avettand-Fenoel et al. AIDS. .

Abstract

Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels.

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