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. 1991;11(1):20-3.
doi: 10.1007/BF02893182.

Effects of benzyltetrahydropalmatine on delayed after depolarization and triggered activity and on His-bundle electrogram and ECG in animal experiment

W X Yao  1 , M X Jiang, G J Xia, W Z Zeng
Affiliations

Effects of benzyltetrahydropalmatine on delayed after depolarization and triggered activity and on His-bundle electrogram and ECG in animal experiment

W X Yao et al. J Tongji Med Univ. 1991.

Abstract

Standard microelectrode techniques were used to study the effects of benzyltetrahydropalmatine (BTHP) on ouabain-induced delayed after depolarization (DAD) and triggered activity in isolated guinea papillary muscles. The results indicate that ouabain-induced DAD and triggered activity were abolished by BTHP 100 mumol/L. In anesthetized rabbit ECG heart rate was reduced in a dose-dependent manner from control value of 288 +/- 14 to 261 +/- 14 (BTHP 5 mg/kg) and 226 +/- 36 bpm (BTHP 10 mg/kg). P-R interval was prolonged. In His-bundle electrogram, H-V interval and V duration were not affected, but A-H interval was prolonged from 41 +/- 3 to 45 +/- 5 ms.

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References

    1. J Cardiovasc Pharmacol. 1989 Feb;13(2):324-7 - PubMed
    1. Cardiovasc Res. 1988 Nov;22(11):818-25 - PubMed
    1. J Pharmacol Exp Ther. 1984 Apr;229(1):188-92 - PubMed

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