Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008;10(5):299-313.
doi: 10.2165/00148581-200810050-00004.

Current management of tuberous sclerosis complex

Darcy A Krueger  1 , David N Franz
Affiliations
Review

Current management of tuberous sclerosis complex

Darcy A Krueger et al. Paediatr Drugs. 2008.

Abstract

Tuberous sclerosis complex (TSC) is an important cause of epilepsy, autism, and renal and pulmonary disease in children and adults. The clinical course of TSC and the prognosis and appropriate therapy for TSC patients are often different than that for individuals with epilepsy, renal tumors, or interstitial lung disease from other causes. This article reviews the current therapeutic recommendations for medical and surgical management of neurologic, renal, and pulmonary manifestations of TSC. In addition, recent clinical trials using inhibitors of the mammalian target of rapamycin (mTOR) have demonstrated regression of astrocytomas, angiofibromas, and angiomyoliomas, as well as improved pulmonary function in persons with TSC.

PubMed Disclaimer

References

    1. Epilepsia. 2005 Oct;46(10):1684-6 - PubMed
    1. Epilepsy Res. 1997 Jan;26(2):389-95 - PubMed
    1. J Am Soc Nephrol. 2007 May;18(5):1399-407 - PubMed
    1. Minim Invasive Neurosurg. 2006 Oct;49(5):317-20 - PubMed
    1. Science. 2006 Oct 6;314(5796):144-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources